What is the biochemical pathway of trichomoniasis? - trichomoniasis more condition_symptoms
I think the biochemical route of trichomoniasis, no one has any idea where can I find? Thank you!
Tuesday, November 3, 2009
Trichomoniasis More Condition_symptoms What Is The Biochemical Pathway Of Trichomoniasis?
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Trichomonas vaginalis, a parasitic protozoan and the causative agent of trichomoniasis, lacks de novo synthesis of purine nucleotides and has a single-track recovery of purines, a type of bacterial purine nucleoside phosphorylase and purine nucleoside kinase is. It is generally believed that adenine and guanine to the corresponding nucleosides and are converted to other phosphorylated form AMP and GMP, respectively the first and most fundamental way in the pool of purine nucleotides in the body rebuild. Formycin A, an analogue of adenosine, an inhibitor of the enzyme and in vitro growth of T. vaginalis with an estimated IC50 of 0.27 uM. This inhibition of growth was offset by the addition of adenine in the culture medium, but not by guanine or hypoxanthine. In addition, T. vaginalis can grow in semi-defined medium supplemented with adenine, but not only with guanine or hypoxanthine. Radiolabeling experiments by HPLC analysis of purine nucleotide pool followed in T. vaginalis demonstrated uptake of [8-14C] adenine into adenine and guaninenine nucleotides, and [containing 8-14C] guanine only into guanine nucleotides. Major activities of adenosine deaminase and significant IMP dehydrogenase and GMP synthetase activities in lysates of T. vaginalis have been identified, suggesting a path capable of converting adenine adenosine Good Manufacturing Practices. This plan purine-adenosine is the main precursor of all purine nucleotides in the group of T. vaginalis and the purine nucleoside kinase, a key enzyme in the majority of the purine salvage and a potential target for the fight against trichomoniasis chemotherapy.
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